AGARICUS BLAZEI

About Agaricus Blazei

Agaricus blazei Murill (AbM) is an edible, medicinal mushroom of Brazilian origin. It is used traditionally against a range of diseases, including cancer. Laboratory studies and experiments done in mice have shown that agaricus can stimulate the immune system and has anticancer effects. Compounds present in agaricus may prevent the formation of blood vessels needed for tumor development. The polysaccharides phytocomplex is thought to be responsible for its immunostimulant and antitumor properties, probably through an opsonizing biochemical pathway. Clinical studies are positive confirmations, but we are still at the beginning.

Recommended Dosage:
3 X daily of 500mg

A small number of patients may be alergic to it.

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How Agaricus Blazei might help

Ergosterol, a major constituent of agaricus, was found to inhibit tumor growth in mice via direct inhibition of tumor-induced angiogenesis. Other studies demonstrated that polysaccharides present in agaricus extract caused activation of macrophages or natural killer cells and induced cytotoxic T-lymphocyte activity in tumor-bearing mice. Specifically, activation of natural killer cells was mediated through IL-12-induced IFN-gamma expression. Agaricus extract stimulates caspase 3 activation and reduces telomerase activity possibly through regulation of Akt signaling thereby inducing apoptosis in cancer cell lines. Blazeispirol A, produced by agaricus fermentation, causes both caspase-dependent and -independent cell death in human Hep 3B cells. Agaritine, a hydrazine-containing constituent also exhibits antitumor activity toward U937 leukemic cells mediated through apoptosis. In another study, polysaccharides isolated from agaricus were shown to induce apoptosis in HL-60 cells through a signaling cascade of mitochondrial caspase-3-dependent pathway.